I always use at least these two rules on defense. The first one controls which sets the defense will use when the offense lines up in a 230 set. The AI lines the defense up in a Goal Line set, which is great against a run, but it leaves receivers wide open if they run the sole pass play from that set. So I like to do something different.
The second Plays only keys pass against any offensive sets that have either no RB or no running plays.
